Endocrine Abstracts

PTSD is an anxiety disorder that occurs among persons exposed to a traumatic event involving life threat and injury. This is a co-morbid psychiatric disorder that occurs along with depression. Cortisol, secreted in the adrenal cortex in response to stress, is an informative biomarker that distinguishes anxiety disorders such as major depression and post-traumatic stress disorder (PTSD) from normal subjects. In comparison to normal subjects, hypocortisolemia was observed during...

Objective: To evaluate the outcome of preoperative therapy with ketoconazole (KTZ) and/or metyrapone (MTP), in previously untreated CS patients who later underwent surgery.Design and methods: A total of 62 CS patients (85% ACTH-dependent), who have been treated with steroidogenesis inhibitors prior to surgery in our centre between 1983 and 2010, were retrospectively studied. T0 and t1 defined visit at baseline and at the end of medical treatment, respect...

Introduction: In the last years, has produced an increment in diagnosis of thyroid cancer. Incidental thyroid carcinoma is defined as a tumour diagnosed after surgery for benign lesions.Aim. The objective of this study was to assess the clinical presentation, tumour characteristics and follow-up.Patients and methods: We analysed clinicopathologic data of incidentally thyroid carcinoma from 351 thyroid surgeries carry out in our hos...

Introduction: The incidence of end stage renal failure (ESRF) secondary to diabetes mellitus (DM) is increasing worldwide. Renal replacement therapy, which if started early improves prognosis, is a common treatment for ESRF.Objective: To determine the waiting time and factors that influence the provision of emergency renal replacement therapy in patients with ESRF secondary to DM admitted to the emergency room of a tertiary care hospital.<p class="ab...

Denosumab discontinuation (DD) induces an increase of B-crosslaps above baseline values for two years, and a decrease of BMD values. This rebound effect is associated with spontaneous clinical vertebral fractures (SCVF) in close to 15% of patients considering a follow-up of 2 years without taking another osteoporosis treatment. We report the clinical characteristics of 31 patients evaluated at our center from July 2015 to January 2018.Results: Thirty wom...

BackgroundSuspicion of Cushing´s syndrome (CS) is usually suggested by non-specific clinical data. Chronic hypercortisolism associates changes in white blood cell count (WBC), essentially a higher count with relative lymphopenia. Our purpose is to investigate the prevalence of these findings among a local series of patients with Cushing’s syndrome before and after the hypercortisolism revertion to assess the diagnostic value of these parameters...

Background: heterophilic antibodies are antibodies in patients’ sample that can cause false results by binding to the assay antibodies. Interference due to heterophilic antibodies may lead to falsely low or high analytic concentrations. In some settings, the relationship between TSH and thyroid hormones does not fit with the expected feedback mechanisms. This may be due to a pathophysiological process, laboratory error or assay interference.Case rep...

Introduction: Our group has a bank of human primary thyroid cultures (BANTTIC) obtained from patients. All are individual cultures specifically genotyped and phenotyped. We believe of great interest the search for biomarkers in these cultures using differential proteomic analysis.We have applied differential proteomics using 2D-PAGE coupled to MALDI-TOF-TOF-MS. We have compared benign pathologies (normal thyroid and Pendred’s syndrome) and different...

Early diagnosis of CS could reduce the morbidity and mortality associated with endogenous hypercortisolism. Many clinical methods have been proposed to establish suspicion of CS, but they show a poor positive predictive value (PPV) and are sometimes difficult to assess. Assuming the well-known influence of hypercortisolism on white blood cell (WBC) count, we evaluated its potential usefulness as a screening test to trigger this suspicion. We analysed WBC count around the diagn...

Introduction: Fine-needle biopsy with cytologic evaluation remains the diagnostic test of choice to distinguish benign from malignant thyroid nodules, but fails to classify thyroid nodules in 15% to 30% of cases (indeterminate thyroid nodules-ITN). ‘Rule out’ molecular testing improves the diagnostic accuracy, with high sensitivity and negative predictive value, ranging from 86 to 96%. However, these tests are not widely available, and notably increase costs. <p ...